The only thing I can think of, is the Arkansas game in Fayetteville last year. Arkansas had already won in Rupp and somehow Cal got the win @ Arkansas without Cason Wallace, Sahvir Wheeler and Ugo. That’s 20ppg, but to your point, it's not 49% of the scoring. They actually won easily (88-79).
But in true Calipari fashion, he turned around and lost the very next game in the SECT to Vanderbilt.
KU was already really thin, taking McCullar and Hunter away, is an impossible hill to climb and Cincinnati is surprisingly good.