This thread is tailor-made for Purdue fans in the past decade.
2010 - Robbie Hummel tears his ACL on Feb. 24 at Minnesota with Purdue ranked No. 3 and heading towards a one seed. The Boilers still win a share of the B1G, but end up being a four seedand losing to Duke in the Sweet 16
2011 - Robbie Hummel tears his ACL in the first practice of the season. Purdue still has a really successful regular season led by B1G POY JaJuan Johnson and E'Twaun Moore and get a three seed. But they get piped by VCU in the Round of 32 during the three weeks that made Shaka Smart way too much money.
2018 - Isaac "the walking petri dish" Haas fractures his elbow during 2-Seed Purdue's Round of 64 boatrace of Cal State Fullerton. Purdue goes on to lose in the Sweet 16 to Texas Tech and their coach who loves to break Boiler hearts in March. The play that caused the injury spawned the hook-and-hold rule that has cost all of us way too many hours watching official reviews this season.