I think whoever wins the SEC will likely be the #1 overall seed. Auburn, Tennessee, Alabama, or whoever will have twice as many Q1 games, and likely twice as many Q1 wins (if not more), than Duke. I'd put hard money on the SEC champ being the top overall seed.
FWIW, I'd rather go in the East Region. The NYC metropolitan area has more Duke graduates than any other region in the country outside of the research triangle in NC. It's nice because you have the influx of Duke fans without the distraction of UNC noise that will often outnumber us at neutral court arenas.