Duke is inevitably going to be #1 this year, and will probably stay there the majority of the remainder of the season.
Auburn, Iowa St, Bama, UT, UF, UK, Marquette, all of which would probably be the only other teams to have the potential to make a case later on down the road depending on potential big wins, are all going to take losses, and multiple losses at that. Just the nature of the conferences they play in, especially the SEC this year.
Duke plays NOBODY in the ACC, and a defacto home game at MSG against Illinois.
The better question to ask, in my opinion, is does Duke deserve a one seed?